Triethylamine → HCID 54536594, compound

HRID 1756760Notes

Reaction equation

HRID 1756760 reaction equation
[CH2:1]1[O:9][C:8]2[C:3](=[C:4]([CH:10]([CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[CH2:11][OH:12])[CH:5]=[CH:6][CH:7]=2)[O:2]1.C(N(CC)CC)C.[CH3:25][S:26](Cl)(=[O:28])=[O:27]>C(Cl)Cl>[CH3:25][S:26]([O:12][CH2:11][CH:10]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[O:9][CH2:1][O:2][C:3]=12)[CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])(=[O:28])=[O:27]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 54450288HCID 54450288, compound

Product 1

HCID 54536594HCID 54536594, compoundYield 99.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 6.65 g (28.1 mmol) of 2-(2, 3-methylenedioxyphenyl)heptanol in 80 ml of methylene chloride was added 4.30 ml (30.9 mmol) of triethylamine, and 2.28 ml (29.5 mmol) of methanesulfonyl chloride was dropwise added. The reaction mixture was stirred at room temperature for 30 minutes, washed with water twice, dried over anhydrous magnesium sulfate and the solvent was evaporated to give 8.76 g of 2-(2, 3-methylenedioxyphenyl)heptyl methanesulfonate as an oil.

Workup

  1. additionwas dropwise added
  2. washwashed with water twice
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customthe solvent was evaporated

Sources & evidence

ORD record
ord-c197f0cf51374bc095b5b5a5a4649c7f
Source dataset
uspto-grants-1995_08
Patent number
US05442060

Reaction notes

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