反应详情

With cooling with ice, aqueous 1 N sodium hydroxide solution (536 μl, 0.536 mmol) was added to an ethanol (3.5 ml) solution of ethyl 4-({4-cyano-7-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-5-methyl-6-phenyl-1,3-benzoxazol-2-yl}amino)butanoate (I-281) (170 mg, 0.357 mmol), followed by stirring at room temperature for 15 hours. With cooling with ice, aqueous 1 N hydrochloric acid solution (536 μl, 0.536 mmol) was added to the reaction liquid, followed by concentration under reduced pressure. The resulting residue was purified by preparative TLC (eluent, chloroform:methanol=5:1, v/v) to obtain the entitled compound (110 mg, 69%) as a pale brown foamy substance.

1. additionwas added to the reaction liquid
2. concentrationfollowed by concentration under reduced pressure
3. customThe resulting residue was purified by preparative TLC (eluent, chloroform