4-Fluorobenzonitrile → 1-(4-Cyanophenyl)piperidine-4-carboxylic acid

HRID 1757002Notes

Reaction equation

HRID 1757002 reaction equation
C(C1C=CC(N2CCC(N[C:16]([O:18]C(C)(C)C)=[O:17])CC2)=CC=1)#N.F[C:24]1[CH:31]=[CH:30][C:27]([C:28]#[N:29])=[CH:26][CH:25]=1.C(O[CH:37]1[CH2:42][CH2:41][N:40](N=C=O)[CH2:39][CH2:38]1)(C)(C)C>>[C:16]([CH:37]1[CH2:38][CH2:39][N:40]([C:24]2[CH:31]=[CH:30][C:27]([C:28]#[N:29])=[CH:26][CH:25]=2)[CH2:41][CH2:42]1)([OH:18])=[O:17]

Participants

4

Reactant 3

HCID 145174-FluorobenzonitrileHCID 2794821tert-butyl N-[1-(4-cyanophenyl)piperidin-4-yl]carbamateHCID 131719088HCID 131719088, compound

Product 1

HCID 193914381-(4-Cyanophenyl)piperidine-4-carboxylic acid

Procedure

1-(4-cyanophenyl)-4-tert.butyloxycarbonylamino-piperidine By reacting 4-fluorobenzonitrile with 4-tert.butyloxy-carbonylamino-piperidine

Sources & evidence

ORD record
ord-6c887c3152d24bfeac962a4a817153dc
Source dataset
uspto-grants-1995_08
Patent number
US05442064

Reaction notes

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