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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1757002Generated: November 1, 2026

4-Fluorobenzonitrile → 1-(4-Cyanophenyl)piperidine-4-carboxylic acid

https://huagongshe.com/reaction/1757002

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-FluorobenzonitrileHCID 14517—
Reactanttert-butyl N-[1-(4-cyanophenyl)piperidin-4-yl]carbamateHCID 2794821—
ReactantHCID 131719088HCID 131719088—
Product1-(4-Cyanophenyl)piperidine-4-carboxylic acidHCID 19391438—

Reaction Steps

1-(4-cyanophenyl)-4-tert.butyloxycarbonylamino-piperidine By reacting 4-fluorobenzonitrile with 4-tert.butyloxy-carbonylamino-piperidine

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05442064
Source datasetuspto-grants-1995_08
ORD IDord-6c887c3152d24bfeac962a4a817153dc
Source noteuspto-grants-1995_08