反应详情

D-Glutamic acid (5.88 g), tert-butyl acetate (100 ml) and 70% aqueous perchloric acid (6.3 g) were stirred at laboratory temperature for 4 days. The mixture was then cooled in an ice-water bath and extracted with 0.5 N hydrochloric acid (3×100 ml). The combined aqueous extracts were immediately neutralised with solid sodium bicarbonate. The aqueous solution was extracted with diethyl ether (3×100 ml), the ether extracts pooled, dried over anhydrous sodium sulphate and the ether evaporated in vacuo to give di-tert-butyl-D-glutamate (0.855 g).

1. temperatureThe mixture was then cooled in an ice-water bath
2. extractionextracted with 0.5 N hydrochloric acid (3×100 ml)
3. extractionThe aqueous solution was extracted with diethyl ether (3×100 ml)
4. dry with materialdried over anhydrous sodium sulphate
5. customthe ether evaporated in vacuo