Methanol → HCID 131719091, compound

HRID 1757129Notes

Reaction equation

[NH:1]([C:19]([O:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:20])[C@H:2]([C:4]([N:6]1[CH2:18][CH2:17][CH2:16][C@H:7]1[C:8]([NH:10][C@H:11]([C:13]([OH:15])=O)[CH3:12])=[O:9])=[O:5])[CH3:3].C1(N[CH:36]2[CH2:41]CCCC2)CCCCC1.C(Cl)(Cl)Cl.[CH3:46][OH:47].[OH2:48]>>[NH:1]([C:19]([O:21][CH2:22][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)=[O:20])[C@H:2]([C:4]([N:6]1[CH2:18][CH2:17][CH2:16][C@H:7]1[C:8]([NH:10][CH:11]([C:13]([C:46]([O:48][CH2:41][CH3:36])=[O:47])=[O:15])[CH3:12])=[O:9])=[O:5])[CH3:3]

Participants

Reactant 5

HCID 887Methanol

HCID 962Water

HCID 6212Chloroform

HCID 7582Dicyclohexylamine

HCID 71395958N-[(Benzyloxy)carbonyl]-L-alanyl-L-prolyl-L-alanine

Product 1

HCID 131719091HCID 131719091, compoundYield 19%

Procedure

This compound was prepared from Z-Ala-Pro-Ala-OH.dicydohexylamine in 19% yield by the procedure described in Example PKC1; single spot on tlc, Rf2 =0.55 (CHCl3 :MeOH=9:1); MS, m/e=447 (M+). Anal. Calcd. for C22H29O7N3.1/2 H2O: C, 57.88; H, 6.62; N, 9.21. Found: C, 57.65; H, 6.68; N, 9.17.

Sources & evidence

ORD record: ord-e61d35ab62384160ab1495c462cbe5c2
Source dataset: uspto-grants-1995_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05444042

Reaction notes

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