HRID1757135

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6212

Chloroform

CHCl3

结构：CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O

HCID7408339

未命名化合物

HCID66729449

未命名化合物

结构：CCOC(=O)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1

HCID131719097

未命名化合物

PRODUCTS

生成物

结构：CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)OCc1ccccc1

HCID131719099

未命名化合物

收率 17%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID244

Benzyl alcohol

C7H8O

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

This compound was prepared from Z-Leu-Phe-OH and benzyl oxalyl chloride in 17% yield by the procedure described in the synthesis of Z-Leu-Phe-CO2Et, except that benzyl oxalyl chloride was used in place of ethyl oxalyl chloride and sodium benzyloxide in benzyl alcohol was used for enol ester hydrolysis. Single spot on TLC, Rf =0.63 (CHCl3 :CH3OH=50:1). Pale yellow solid, mp 117°-119° C. MS(FAB) m/e=532 (m+1). H1NMR ok.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-dbdb081ab12a4314bb1b24f306d5d73e
来源数据集: uspto-grants-1995_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05444042
来源说明: uspto-grants-1995_08

反应 SMILES

[NH:1]([C:21]([O:23][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:22])[C@H:2]([C:7]([NH:9][C@H:10]([C:18]([OH:20])=O)[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].N([C:55]([O:57][CH2:58][C:59]1[CH:64]=[CH:63][CH:62]=[CH:61][CH:60]=1)=[O:56])[C@H](C(N[C@H](C(C(OCC)=O)=O)CC1C=CC=CC=1)=O)CC(C)C.C(OCC1C=CC=CC=1)C1C=CC=CC=1.[Na].C(Cl)(Cl)Cl>C(O)C1C=CC=CC=1.CO>[NH:1]([C:21]([O:23][CH2:24][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)=[O:22])[C@H:2]([C:7]([NH:9][C@H:10]([C:18]([C:55]([O:57][CH2:58][C:59]1[CH:64]=[CH:63][CH:62]=[CH:61][CH:60]=1)=[O:56])=[O:20])[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5]