HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → Z-Leu-Phe-CO2Bzl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Z-Leu-phe-OH | HCID 7408339 | — |
| Reactant | CID 66729449 | HCID 66729449 | — |
| Reactant | Z-Leu-Phe-CO2Et | HCID 131719097 | — |
| Solvent | Benzyl Alcohol | HCID 244 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Z-Leu-Phe-CO2Bzl | HCID 131719099 | 17% |
Reaction Steps
This compound was prepared from Z-Leu-Phe-OH and benzyl oxalyl chloride in 17% yield by the procedure described in the synthesis of Z-Leu-Phe-CO2Et, except that benzyl oxalyl chloride was used in place of ethyl oxalyl chloride and sodium benzyloxide in benzyl alcohol was used for enol ester hydrolysis. Single spot on TLC, Rf =0.63 (CHCl3 :CH3OH=50:1). Pale yellow solid, mp 117°-119° C. MS(FAB) m/e=532 (m+1). H1NMR ok.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05444042 |
| Source dataset | uspto-grants-1995_08 |
| ORD ID | ord-dbdb081ab12a4314bb1b24f306d5d73e |
| Source note | uspto-grants-1995_08 |