Methyl iodide → HCID 19390114, compound

HRID 1757162Notes

Reaction equation

HRID 1757162 reaction equation
[F:1][C:2]1[C:3]([OH:13])=[C:4]([CH:9]=[C:10]([F:12])[CH:11]=1)[CH2:5][N:6]([CH3:8])[CH3:7].[CH3:14][I:15]>C(Cl)(Cl)Cl>[I-:15].[F:1][C:2]1[C:3]([OH:13])=[C:4]([CH:9]=[C:10]([F:12])[CH:11]=1)[CH2:5][N+:6]([CH3:14])([CH3:8])[CH3:7]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 193901012-[(Dimethylamino)methyl]-4,6-difluorophenol

Product 1

HCID 19390114HCID 19390114, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

74 g (0.40 mol) of 3,5-difluoro-2-hydroxy-N,N-dimethylbenzylamine was dissolved in 300 ml of chloroform, and 200 ml of methyl iodide was added thereto. The mixture was heated under reflux for 3 hr to deposit a yellow precipitate. The precipitate was recovered by filtration to prepare 114 g (yield: 87%) of the intended product.

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 3 hr
  3. filtrationThe precipitate was recovered by filtration

Sources & evidence

ORD record
ord-930c03ff64fb4ccd92b94561a23781ae
Source dataset
uspto-grants-1995_08
Patent number
US05444083

Reaction notes

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