Hydrochloric Acid → HCID 15284533, compound

HRID 1757185Notes

Reaction equation

HRID 1757185 reaction equation
[CH2:1]([C:5]1[N:6]([CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[Cl:29])[C:7]([CH2:10][CH:11]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:12]([OH:14])=[O:13])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4].[CH2:30](OCC)C.Cl>CO>[CH2:1]([C:5]1[N:6]([CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[Cl:29])[C:7]([CH2:10][CH:11]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:12]([O:14][CH3:30])=[O:13])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 15284532HCID 15284532, compound

Product 1

HCID 15284533HCID 15284533, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-benzylpropanoic acid [Example 8] (0.5 g) was dissolved in methanol (100 mL) and treated with excess diethyl ether saturated with dry hydrochloric acid. The mixture was kept at 25° C. for 48 hours. The solvents were evaporated, the residue dissolved in a small amount of methanol. Crystallization was induced with diethyl ether. The solid was collected, washed with diethyl ether, and dried to afford 0.47 g (90%) of the title compound; mp 118.5°-120.5° C.

Workup

  1. customThe solvents were evaporated
  2. dissolutionthe residue dissolved in a small amount of methanol
  3. customCrystallization
  4. customThe solid was collected
  5. washwashed with diethyl ether
  6. customdried

Sources & evidence

ORD record
ord-0a270b33c75849c89f0d13030096d6eb
Source dataset
uspto-grants-1995_08
Patent number
US05444080

Reaction notes

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