HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethyl phosphite → HCID 15234843, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethyl phosphite | HCID 8472 | — |
| Reactant | 4-(Bromomethyl)-2,5-dihydrofuran-2-one | HCID 590264 | — |
| Product | HCID 15234843 | HCID 15234843 | — |
Reaction Steps
A solution 15.0 g of 4-bromomethyl-2-oxo-[5H]-furan (Martin R. et al., Helv.Chim. Acta, 1976, 59, 2724) in 100 ml of trimethylphosphite was refluxed for 2 hrs, while a stream of nitrogen was bubbled vigorously into the solution. The mixture was then evaporated to dryness and the residue was purified by chromatography (SiO2 ; ethyl acetate/diethylether 50/50) to give 16.0 g of dimethyl (2-oxo-[5H]-4-furyl)methyl-phosphonate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05444082 |
| Source dataset | uspto-grants-1995_08 |
| ORD ID | ord-8b40b98def1a4ccd8e506725fe5b8871 |
| Source note | uspto-grants-1995_08 |