Trimethyl phosphite → HCID 15234843, compound

HRID 1757218Notes

Reaction equation

HRID 1757218 reaction equation
Br[CH2:2][C:3]1[CH2:7][O:6][C:5](=[O:8])[CH:4]=1.[CH3:9][O:10][P:11]([O:14]C)[O:12][CH3:13]>>[O:8]=[C:5]1[CH:4]=[C:3]([CH2:2][P:11](=[O:14])([O:12][CH3:13])[O:10][CH3:9])[CH2:7][O:6]1

Participants

3

Reactant 2

HCID 8472Trimethyl phosphiteHCID 5902644-(Bromomethyl)furan-2(5H)-one

Product 1

HCID 15234843HCID 15234843, compound

Procedure

A solution 15.0 g of 4-bromomethyl-2-oxo-[5H]-furan (Martin R. et al., Helv.Chim. Acta, 1976, 59, 2724) in 100 ml of trimethylphosphite was refluxed for 2 hrs, while a stream of nitrogen was bubbled vigorously into the solution. The mixture was then evaporated to dryness and the residue was purified by chromatography (SiO2 ; ethyl acetate/diethylether 50/50) to give 16.0 g of dimethyl (2-oxo-[5H]-4-furyl)methyl-phosphonate.

Workup

  1. customwas bubbled vigorously into the solution
  2. customThe mixture was then evaporated to dryness
  3. customthe residue was purified by chromatography (SiO2 ; ethyl acetate/diethylether 50/50)

Sources & evidence

ORD record
ord-8b40b98def1a4ccd8e506725fe5b8871
Source dataset
uspto-grants-1995_08
Patent number
US05444082

Reaction notes

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