HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid monohydrate → cis-3-Hydroxy-2-phenylpiperidinium tosylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | 3-Hydroxy-2-phenylpiperidine | HCID 18782643 | — |
| Product | cis-3-Hydroxy-2-phenylpiperidinium tosylate | HCID 86748915 | — |
Reaction Steps
The mixture of cis- and trans-isomers of 3-hydroxy-2-phenylpiperidine (Description 1, (2b)) and 4-toluenesulfonic acid monohydrate was crystallized from methanol/ethyl acetate to give cis-3-hydroxy-2-phenylpiperidinium tosylate: mp 266°-267° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05444074 |
| Source dataset | uspto-grants-1995_08 |
| ORD ID | ord-3d7c5dbc015b43c1a7c59c9e2e8ac828 |
| Source note | uspto-grants-1995_08 |