2-Hepten-4-yne, 1-bromo-6,6-dimethyl- → (E)-2-(6,6-dimethyl-2-hepten-4-ynyl)-3-[3-[3-(3-thienyl)phenylmethoxy]phenyl]propionic acid methyl ester

HRID 1757270Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1757270
[CH3:1][C:2]([CH3:10])([CH3:9])[C:3]#[C:4][C:5]#[C:6][CH2:7]Br.BrCC1[CH:14]=[C:15](C=CC=1)[O:16][CH2:17]C1SC=C(C2C=CSC=2)C=1.ICCCCC[O:37]C1C=C(C2C=CSC=2)C=CC=1.ICCCC/C=C/C1C=C(C2C=CSC=2)C=CC=1.CC(C)(C)C#C/C=C/CBr.Br[CH2:78][C:79]1[CH:80]=[C:81]([CH:95]=[CH:96][CH:97]=1)[O:82][CH2:83][C:84]1[CH:85]=[C:86]([C:90]2[CH:94]=[CH:93][S:92][CH:91]=2)[CH:87]=[CH:88][CH:89]=1>>[CH3:17][O:16][C:15](=[O:37])[CH:14]([CH2:7]/[CH:6]=[CH:5]/[C:4]#[C:3][C:2]([CH3:10])([CH3:9])[CH3:1])[CH2:78][C:79]1[CH:97]=[CH:96][CH:95]=[C:81]([O:82][CH2:83][C:84]2[CH:89]=[CH:88][CH:87]=[C:86]([C:90]3[CH:94]=[CH:93][S:92][CH:91]=3)[CH:85]=2)[CH:80]=1

Komponenten

7

Edukt 6

HCID 110744282-Hepten-4-yne, 1-bromo-6,6-dimethyl-HCID 193901352-(3-Bromomethylphenoxymethyl)-4-(3-thienyl)thiopheneHCID 193901653-[3-(5-Iodopentanoxy)phenyl]thiopheneHCID 193901786,6-Dimethyl-2,4-heptadiynyl bromideHCID 19390204(E)-3-[3-(6-iodo-1-hexenyl)phenyl]thiopheneHCID 193902053-[3-(3-Bromomethylphenoxymethyl)phenyl]thiophene

Produkt 1

HCID 86748937(E)-2-(6,6-dimethyl-2-hepten-4-ynyl)-3-[3-[3-(3-thienyl)phenylmethoxy]phenyl]propionic acid methyl ester

Versuchsvorschrift

(E,E)-2-(6,6-dimethyl-2-hepten-4-ynyl)-3-[3-[2-[3-(3-thienyl)phenyl]ethenyl]phenyl]propionic acid methyl ester, (E)-2-(6,6-dimethyl-2-hepten-4-ynyl)-3-[3-[4-(3-thienyl)-2-thienylmethoxy]phenyl]propionic acid methyl ester, (E)-2-(6,6-dimethyl-2,4-heptadiynyl)-3-[3-[2-[3-(3-thienyl)phenyl]ethenyl]phenyl]propionic acid methyl ester, (E)-2-(6,6-dimethyl-2-hepten-4-ynyl)-7-[3-(3-thienyl)phenoxy]heptanoic acid methyl ester and (E,E)-2-(6,6-dimethyl-2-hexen-4-ynyl)-8-[3-(3-thienyl)phenyl]-7-octenoic acid methyl ester are obtained by carrying out the same reactions as in Referential Example 4 except that 6,6-dimethyl-2,4-heptadiynyl bromide and/or (E)-3-[3-[2-[3-(3-bromomethylphenyl)ethenyl]phenyl]thiophene, 2-(3-bromomethylphenoxymethyl)-4-(3-thienyl)thiophene, 3-[3-(5-iodopentanoxy)phenyl]thiophene or (E)-3-[3-(6-iodo-1-hexenyl)phenyl]thiophene are used, respectively, in place of (E)-6,6-dimethyl-2-hepten-4-ynyl bromide and/or 3-[3-(3-bromomethylphenoxymethyl)phenyl]thiophene which are the raw material compounds used in the above reaction.

Aufarbeitung

  1. customused in the above reaction

Quellen und Nachweise

ORD-Eintrag
ord-9d26afc188fe492f84eaf3c9357252d6
Quelldatensatz
uspto-grants-1995_08
Patentnummer
US05444084

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