Methanol → HCID 67788876, compound

HRID 1757285Notes

Reaction equation

HRID 1757285 reaction equation
O[O:2][S:3]([O-:5])=O.[K+].[CH2:7]([C:9]1[CH2:18]C(=S)[C:16]2[C:11](=[CH:12][CH:13]=[C:14](C)[CH:15]=2)[N:10]=1)[CH3:8].[C:21](=[O:24])(O)[O-].[Na+].[CH3:26]O>O>[CH2:7]([C:9]1[CH2:18][C:21](=[O:24])[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([S:3]([CH3:26])(=[O:5])=[O:2])[CH:15]=2)[N:10]=1)[CH3:8]

Participants

6

Reactant 4

HCID 887MethanolHCID 516892Sodium BicarbonateHCID 23707502Potassium hydroxy sulfiteHCID 86748929HCID 86748929, compound

Product 1

HCID 67788876HCID 67788876, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Oxone (920 mg) was added to a solution of 2-ethyl-6-methylthio-4-quinolone (220 mg) in methanol (10 ml) and water (1 ml). The suspension was stirred at ambient temperature for 1 hour then evaporated to give a yellow solid. Saturated sodium bicarbonate solution (10 ml) was added and the resulting precipitate collected by filtration and dried to give 2-ethyl-6-methylsulphonyl-4-quinolone (150 mg) as a light yellow powder, m.p. 283° C.

Workup

  1. customthen evaporated
  2. customto give a yellow solid
  3. filtrationthe resulting precipitate collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-0b50e5ebd28342048bef26a8d4c89569
Source dataset
uspto-grants-1995_08
Patent number
US05444071

Reaction notes

Loading…