HCID 178447811, compound → HCID 178447806, compound

HRID 1757346Notes

Reaction equation

HRID 1757346 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([Mg]Br)[CH:5]=[C:6]([F:9])[C:7]=1[F:8].[CH2:12]([C@H:15]1[CH2:20][CH2:19][C@H:18]([CH:21]2[CH2:24][C:23]3([CH2:27][C:26](=[O:28])[CH2:25]3)[CH2:22]2)[CH2:17][CH2:16]1)[CH2:13][CH3:14]>C(OCC)C>[CH2:12]([C@H:15]1[CH2:16][CH2:17][C@H:18]([CH:21]2[CH2:22][C:23]3([CH2:27][C:26]([OH:28])([C:4]4[CH:3]=[C:2]([F:1])[C:7]([F:8])=[C:6]([F:9])[CH:5]=4)[CH2:25]3)[CH2:24]2)[CH2:19][CH2:20]1)[CH2:13][CH3:14]

Participants

4

Reactant 2

HCID 178447811HCID 178447811, compoundHCID 178505944HCID 178505944, compound

Product 1

HCID 178447806HCID 178447806, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 15 mmol of 3,4,5-trifluorophenylmagnesium bromide (prepared from 3,4,5-trifluorobromobenzene and magnesium turnings), 15 mmol of 4E and 50 ml of diethyl ether is stirred for 15 hours. After conventional work-up the product is obtained, which is processed further without purification.

Workup

  1. customAfter conventional work-up the product is obtained
  2. customwhich is processed further without purification

Sources & evidence

ORD record
ord-6aa4a8a0be1247b5a78460944dc6a107
Source dataset
uspto-grants-1995_08
Patent number
US05445764

Reaction notes

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