Nitric Acid → HCID 178418997, compound

HRID 1757348Notes

Reaction equation

HRID 1757348 reaction equation
[N+:1]([O-:4])(O)=[O:2].N[C:6]1[CH:11]=[CH:10][C:9]([Br:12])=[CH:8][N:7]=1.S(=O)(=O)(O)[OH:14]>>[Br:12][C:9]1[CH:10]=[C:11]([N+:1]([O-:4])=[O:2])[C:6]([OH:14])=[N:7][CH:8]=1

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 706222-Amino-5-bromopyridine

Product 1

HCID 178418997HCID 178418997, compound

Conditions

Temperature
60 °C

Procedure

34.5 ml (821.6 mmol) of fuming nitric acid (d=1.5 g/cm3) are added dropwise at 60° C. to 100 g (574.7 mmol) of 2-amino-5-bromopyridine in 300 ml of concentrated sulfuric acid (d=1.84 g/cm3), and the mixture is subsequently stirred at 60° C. for 2 hours. The reaction mixture is poured into ice water, and the precipitated solid is filtered off, washed with water and dried, giving 88.16 g of 5-bromo-2-hydroxy-3-nitropyridine. ##STR10##

Workup

  1. filtrationthe precipitated solid is filtered off
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-ea62c594a68941f7b1df12cc305ea83a
Source dataset
uspto-grants-1995_08
Patent number
US05445763

Reaction notes

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