Nitric Acid → HCID 178418997, compound

Participants

Reaction Conditions

Reaction Steps

34.5 ml (821.6 mmol) of fuming nitric acid (d=1.5 g/cm3) are added dropwise at 60° C. to 100 g (574.7 mmol) of 2-amino-5-bromopyridine in 300 ml of concentrated sulfuric acid (d=1.84 g/cm3), and the mixture is subsequently stirred at 60° C. for 2 hours. The reaction mixture is poured into ice water, and the precipitated solid is filtered off, washed with water and dried, giving 88.16 g of 5-bromo-2-hydroxy-3-nitropyridine. ##STR10##

Provenance & Evidence