Methane → 2,5-Dibromopyridin-3-amine

HRID 1757350Notes

Reaction equation

HRID 1757350 reaction equation
[Br:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][C:5]([Br:11])=[CH:4][N:3]=1.C.[H][H]>[Pd].CO>[NH2:8][C:7]1[C:2]([Br:1])=[N:3][CH:4]=[C:5]([Br:11])[CH:6]=1

Participants

6

Reactant 3

HCID 297MethaneHCID 2984702,5-Dibromo-3-nitropyridineHCID 178418361HCID 178418361, compound

Product 1

HCID 193875322,5-Dibromopyridin-3-amineYield 0.1%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 23938PalladiumSolvent

Procedure

43.00 g (152.52 mol) of 2,5-dibromo-3-nitropyridine are hydrogenated in 1.5 g of Pd (10%) on activated charcoal in 450 ml of methanol until the calculated mount of hydrogen has been consumed, the catalyst is filtered off, and the filtrate is freed from solvent, giving 37.56 g of 3-amino-2,5-dibromopyridine. ##STR12##

Workup

  1. customhas been consumed
  2. filtrationthe catalyst is filtered off

Sources & evidence

ORD record
ord-680f977c346c4a5ca09c4ea38a4afcfd
Source dataset
uspto-grants-1995_08
Patent number
US05445763

Reaction notes

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