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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1757366Generated: October 29, 2026

1-Octanol → 2-(Tert-butyldiphenylsilyloxyphenyl)-3-fluoro-5-octyloxypyridine

https://huagongshe.com/reaction/1757366

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-OctanolHCID 957—
Reactant2-(4-Tert-butyldiphenylsilyloxyphenyl)-3-fluoro-5-hydroxypyridineHCID 19387531—
Reactant5-Bromo-2-(4-tert-butyldiphenylsilyloxyphenyl)-3-fluoropyridineHCID 19387540—
Product2-(Tert-butyldiphenylsilyloxyphenyl)-3-fluoro-5-octyloxypyridineHCID 19387552—

Reaction Steps

5-bromo-2-(4-tert-butyldiphenylsilyloxyphenyl)-3-fluoropyridine is converted analogously to Example 2 into 2-(4-tert-butyldiphenylsilyloxyphenyl)-3-5-hydroxypyridine. ##STR32## 2-(4-tert-butyldiphenylsilyloxyphenyl)-3-fluoro-5-hydroxypyridine and octanol are reacted analogously to Example 2 to give 2-(tert-butyldiphenylsilyloxyphenyl)-3-fluoro-5-octyloxypyridine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05445763
Source datasetuspto-grants-1995_08
ORD IDord-b5bbc95f787d4e9da71b9ed0b80b2e88
Source noteuspto-grants-1995_08