Hydrochloric Acid → HCID 15029627, compound

HRID 1757385Notes

Reaction equation

HRID 1757385 reaction equation
Cl.[F:2][C:3]1[CH:12]=[C:11]([F:13])[CH:10]=[C:9]2[C:4]=1[C:5](=[O:19])[CH:6]=[C:7]([O:15][CH:16](C)C)[C:8]2=[O:14]>CO>[F:2][C:3]1[CH:12]=[C:11]([F:13])[CH:10]=[C:9]2[C:4]=1[C:5](=[O:19])[CH:6]=[C:7]([O:15][CH3:16])[C:8]2=[O:14]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15029626HCID 15029626, compound

Product 1

HCID 15029627HCID 15029627, compoundYield 83.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 0.48 g (13.2 mM) of anhydrous hydrogen chloride in 15 mL of methanol was treated with 0.175 g (0.694 mM) of 5,7-difluoro-2-isopropoxy-1,4-naphthoquinone. The mixture was heated to solvent reflux temperature for 0.33 hours, cooled to room temperature and concentrated in vacuo to give 0.13 g of product. 1H NMR (dmso-d6): δ=7.8 (m, 1H), 7.68 (dd, 1H, JH-Fortho =7.5Hz),6.31 (s, 1H), 3.86(s, 3H).

Workup

  1. temperatureThe mixture was heated to solvent
  2. temperaturereflux temperature for 0.33 hours
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-72a1fde9a5644ffd8d8815861da22ee0
Source dataset
uspto-grants-1995_08
Patent number
US05446039

Reaction notes

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