Hydrochloric Acid → 5440-22-2

HRID 1757388Notes

Reaction equation

HRID 1757388 reaction equation
C([NH:4][CH:5]([CH:9]([CH3:11])[CH3:10])[C:6](=[O:8])[CH3:7])(=O)C.[ClH:12]>C(O)C>[ClH:12].[O:8]=[C:6]([CH:5]([NH2:4])[CH:9]([CH3:11])[CH3:10])[CH3:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12344670HCID 12344670, compound

Product 1

HCID 149026415440-22-2Yield 63%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of N-acetyl-2-keto-3-amino-4-methylpentane (6.33 g, 40.3 mmol) and 6M hydrochloric acid (65 ml) was heated at reflux overnight. The reaction mixture was cooled to room temperature, ethanol (100 ml) was added and the mixture concentrated under reduced pressure. The mixture wastriturated with ether to give a precipitate which was collected by filtration. Crystallisation from acetone gave 2-keto-3-amino-4-methylpentane hydrochloride (2.9 g, 63%) as a white crystalline solid.

Workup

  1. temperaturewas heated
  2. temperatureat reflux overnight
  3. concentrationthe mixture concentrated under reduced pressure
  4. customto give a precipitate which
  5. filtrationwas collected by filtration
  6. customCrystallisation from acetone

Sources & evidence

ORD record
ord-20cac4779c2844f79173efd66edf5f6a
Source dataset
uspto-grants-1995_08
Patent number
US05446032

Reaction notes

Loading…