Bromomethyl 4-methoxyphenyl ketone → HCID 15388729, compound

HRID 1757389Notes

Reaction equation

HRID 1757389 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[S:8][CH2:9][C:10](=[O:13])[NH:11][N:12]=2)=[CH:3][CH:2]=1.[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]([CH2:24][Br:25])=[O:23])=[CH:18][CH:17]=1>C(O)C>[Br-:25].[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]([CH2:24][N+:1]2[CH:2]=[CH:3][C:4]([C:7]3[S:8][CH2:9][C:10](=[O:13])[NH:11][N:12]=3)=[CH:5][CH:6]=2)=[O:23])=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 4965Bromomethyl 4-methoxyphenyl ketoneHCID 233716232-(Pyridin-4-yl)-4H-1,3,4-thiadiazin-5(6H)-one

Product 1

HCID 15388729HCID 15388729, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-(4-Pyridyl)-4H,6H-1,3,4-thiadiazin-5-one (1.88 g, 9.74 mmol) and 4'-methoxyphenacyl bromide (2.23 g, 9.74 mmol) were dissolved in absolute ethanol (40 ml) and stirred at room temperature for one day. The resultingprecipitate was collected by filtration and washed with absolute ethanol toobtain the titled compound (3.84g) as yellow powder.

Workup

  1. filtrationThe resultingprecipitate was collected by filtration
  2. washwashed with absolute ethanol toobtain the titled compound (3.84g) as yellow powder

Sources & evidence

ORD record
ord-992470f3a70b4544bb6cc068554aca8a
Source dataset
uspto-grants-1995_08
Patent number
US05446042

Reaction notes

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