Acetamide → HCID 9797961, compound

HRID 1757478Notes

Reaction equation

HRID 1757478 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][CH2:13][C:14]2[CH:15]=[C:16]([CH:22]=[CH:23][CH:24]=2)OCCC#N)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[C:25]([NH2:28])(=O)[CH3:26].O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([NH:11][CH2:12][CH2:13][C:14]2[CH:24]=[CH:23][C:22]([CH2:26][CH2:25][NH2:28])=[CH:16][CH:15]=2)(=[O:9])=[O:10])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 178AcetamideHCID 14812Phosphorus oxide (P4O10)HCID 19388141HCID 19388141, compound

Product 1

HCID 9797961HCID 9797961, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
110 °C

Procedure

1-[3-[2-(4-chlorophenylsulphonylamino)-ethyl]-phenoxy]-2-cyanoethane, m.p. 90°-93° C. which can be prepared by heating to 110° C. for 5 hours s mixture of 3-[2-[4-chlorophenylsulphonylamino)-ethyl]-phenoxy]-acetamide (1 mol), P2O5 (2 mol) and toluene. Yield 63% of theory; m.p. 94° C.

Sources & evidence

ORD record
ord-d38c6f0a77094393931c8383c4561915
Source dataset
uspto-grants-1995_08
Patent number
US05446065

Reaction notes

Loading…