HCID 9980291, compound → 1-butyl-2-{2'-[2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl]biphenyl-4-ylmethyl}1H-indole-3-carboxylic acid

HRID 1757500Notes

Reaction equation

HRID 1757500 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]2[N:16]=[N:17][N:18]([C:20]([CH3:28])([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH3:21])[N:19]=2)=[CH:5][CH:4]=1.[CH2:29]([N:33]1[C:41]2[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=2)[C:35]([C:42]([OH:44])=[O:43])=[CH:34]1)[CH2:30][CH2:31][CH3:32]>[Pd]>[CH2:29]([N:33]1[C:41]2[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=2)[C:35]([C:42]([OH:44])=[O:43])=[C:34]1[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]2[N:16]=[N:17][N:18]([C:20]([CH3:28])([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH3:21])[N:19]=2)=[CH:5][CH:4]=1)[CH2:30][CH2:31][CH3:32]

Participants

4

Reactant 2

HCID 9980291HCID 9980291, compoundHCID 103762901-butylindole-3-carboxylic Acid

Product 1

HCID 103707811-butyl-2-{2'-[2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl]biphenyl-4-ylmethyl}1H-indole-3-carboxylic acid

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

reacting the 4-bromomethyl-2'-[2-(1methyl-1-phenylethyl)-2H-tetrazol-5-yl]biphenyl with 2-transmetalated 1-but-1-yl-1H-indole-3-carboxylic acid in the presence of phosphinated palladium catalyst to give 1-butyl-2-[2'-(2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-indole-3-carboxylic acid; and

Sources & evidence

ORD record
ord-544fe69aadc748b98e4519e45f62f4f4
Source dataset
uspto-grants-1995_08
Patent number
US05446121

Reaction notes

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