Thionyl Chloride → 2-(Chloromethyl)anisole

HRID 1757552Notes

Reaction equation

HRID 1757552 reaction equation
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5]O.S(Cl)([Cl:13])=O>ClCCl>[CH3:1][O:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5][Cl:13]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 691542-Methoxybenzyl alcohol

Product 1

HCID 814952-(Chloromethyl)anisole

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

In a nitrogen atmosphere, 2.00 g (14.5 mmol.) of 2-methoxybenzyl alcohol was dissolved in 10 ml of dichloromethane. The obtained solution was placed in an ice-bath, and to this was dropwise added a solution of 1.06 ml (14.6 mmol.) of thionyl chloride in 2 ml of dichloromethane.

Workup

  1. customThe obtained solution was placed in an ice-bath

Sources & evidence

ORD record
ord-3de5538774274086983faba912e5ce46
Source dataset
uspto-grants-1995_08
Patent number
US05446146

Reaction notes

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