HCID 19388574, compound → HCID 10612938, compound

HRID 1757568Notes

Reaction equation

HRID 1757568 reaction equation
Cl.[Cl:2][C:3]1[CH:18]=[C:7]([C:8]([NH:10][CH2:11][CH2:12][N:13]([CH2:16][CH3:17])[CH2:14][CH3:15])=[O:9])[C:6]([OH:19])=[CH:5][CH:4]=1.O1CC[CH2:23]OO1>FC(F)(F)C(O)=O>[Cl:2][C:3]1[CH:4]=[CH:5][C:6]2[O:19][CH2:23][N:10]([CH2:11][CH2:12][N:13]([CH2:16][CH3:17])[CH2:14][CH3:15])[C:8](=[O:9])[C:7]=2[CH:18]=1

Participants

4

Reactant 2

HCID 19388574HCID 19388574, compoundHCID 19593658CID 19593658

Product 1

HCID 10612938HCID 10612938, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

8.00 Grammes (26.1 mmoles) of 5-chloro-N-[2-(diethylamino)ethyl]salicylamide hydrochloride are dissolvedin 100 ml of trifluoroacetic acid with 2.35 grammes (26.1 mmoles) of trioxane and left to react for 20 hours at a temperature of 50° C.

Workup

  1. waitleft
  2. customto react for 20 hours at a temperature of 50° C.

Sources & evidence

ORD record
ord-c9fd3464d8c6444d9605f619c5a2a4a9
Source dataset
uspto-grants-1995_08
Patent number
US05446152

Reaction notes

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