Water → HCID 10619632, compound

Participants

Reaction Steps

2.00 Grammes (7.1 mmoles) of 6-chloro-3-[2-(diethylamino)ethyl]-2,3-dihydro-(1H)-quinazolinone are suspended in 5 ml of anhydrous dimethylacetamide. Milligrammes (17.8 mmoles) of sodium hydride are added to this solution and, after 30 minutesat room temperature, 0.72 ml (7.8 mmoles) of bromomethylcyclohexane are dripped. After 3 hours of reaction at room temperature the reaction solution is poured into water and ice. The product, of an oily consistency, is recovered through extraction with ethyl acetate, with a yield of 85%, and presents the following chemical-physical characteristics.

Provenance & Evidence