Water → HCID 10619632, compound

HRID 1757571Notes

Reaction equation

HRID 1757571 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=O)[N:6]([CH2:13][CH2:14][N:15]([CH2:18][CH3:19])[CH2:16][CH3:17])[CH2:5]2.[H-].[Na+].Br[CH2:23][CH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1.[OH2:30]>CC(N(C)C)=O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:23][CH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1)[CH2:7][N:6]([CH2:13][CH2:14][N:15]([CH2:18][CH3:19])[CH2:16][CH3:17])[C:5]2=[O:30]

Participants

6

Reactant 4

HCID 962WaterHCID 24758Sodium hydrideHCID 137636Cyclohexane, (bromomethyl)-HCID 19388567HCID 19388567, compound

Product 1

HCID 10619632HCID 10619632, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

2.00 Grammes (7.1 mmoles) of 6-chloro-3-[2-(diethylamino)ethyl]-2,3-dihydro-(1H)-quinazolinone are suspended in 5 ml of anhydrous dimethylacetamide. Milligrammes (17.8 mmoles) of sodium hydride are added to this solution and, after 30 minutesat room temperature, 0.72 ml (7.8 mmoles) of bromomethylcyclohexane are dripped. After 3 hours of reaction at room temperature the reaction solution is poured into water and ice. The product, of an oily consistency, is recovered through extraction with ethyl acetate, with a yield of 85%, and presents the following chemical-physical characteristics.

Workup

  1. customAfter 3 hours of reaction at room temperature the reaction solution
  2. customThe product, of an oily consistency, is recovered through extraction with ethyl acetate, with a yield of 85%

Sources & evidence

ORD record
ord-ad534c4b76e7411ab02946b5e48797e6
Source dataset
uspto-grants-1995_08
Patent number
US05446152

Reaction notes

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