反应详情

温度

0 °C

To a solution containing 40 ml of nitric acid (d-1.41) and 40 ml of water was gradually added while cooling (below 7° C.) and stirring 25.0 gof 4'-hydroxy-3'-methoxyacetophenone. After stirring for 0.5 h at 0°C. the product was filtered, washed first with diluted nitric acid (1:1) and then with water. Yield 24.0 g (75%). The 1H-NMR-spectrum of the product was in accordance with the structure alleged.

1. additionwas gradually added
2. temperaturewhile cooling (below 7° C.)
3. filtrationwas filtered
4. washwashed first with diluted nitric acid (1:1)