Hydrogen Bromide → HCID 67804523, compound

HRID 1757673Notes

Reaction equation

HRID 1757673 reaction equation
[OH:1][C:2]1[C:13]([N+:14]([O-:16])=[O:15])=[CH:12][C:5]([CH2:6][C@@H:7]([C:9]([OH:11])=[O:10])[NH2:8])=[CH:4][C:3]=1[O:17]C.[BrH:19]>>[BrH:19].[OH:17][C:3]1[CH:4]=[C:5]([CH:12]=[C:13]([N+:14]([O-:16])=[O:15])[C:2]=1[OH:1])[CH2:6][C@@H:7]([C:9]([OH:11])=[O:10])[NH2:8]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 54191093HCID 54191093, compound

Product 1

HCID 67804523HCID 67804523, compound

Procedure

A solution containing 1.2 g of 4-hydroxy-3-methoxy-5-nitrophenylalanine hydrosulfate in 10 ml of conc. hydrobromic acid was refluxed for 2 h. The solution was concentrated in vacuo and allowed to stand over night in a refrigerator. The product was filtered and washed with hydrobromic acid and dried. Yield 0.25 g, m.p. 170° C. (decomp.).

Workup

  1. temperaturewas refluxed for 2 h
  2. concentrationThe solution was concentrated in vacuo
  3. waitto stand over night in a refrigerator
  4. filtrationThe product was filtered
  5. washwashed with hydrobromic acid
  6. customdried

Sources & evidence

ORD record
ord-493a296204fd4d6aafa0c51a52168bcd
Source dataset
uspto-grants-1995_08
Patent number
US05446194

Reaction notes

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