Ethanol → 4-Ethoxy-6-ethylamino-2-isopropylamino-5-pyrimidinecarbonitrile

HRID 1757905Notes

Reaction equation

HRID 1757905 reaction equation
[Na].Cl[C:3]1[C:8]([C:9]#[N:10])=[C:7]([NH:11][CH2:12][CH3:13])[N:6]=[C:5]([NH:14][C:15]([C:18]#N)([CH3:17])C)[N:4]=1.[CH2:20]([OH:22])[CH3:21]>CO>[CH2:20]([O:22][C:3]1[C:8]([C:9]#[N:10])=[C:7]([NH:11][CH2:12][CH3:13])[N:6]=[C:5]([NH:14][CH:15]([CH3:17])[CH3:18])[N:4]=1)[CH3:21]

Participants

5

Reactant 3

HCID 702EthanolHCID 5360545Sodium2×HCID 538166454-Chloro-2-(1-cyano-1-methylethylamino)-6-ethylamino-5-pyrimidinecarbonitrile

Product 1

HCID 205102004-Ethoxy-6-ethylamino-2-isopropylamino-5-pyrimidinecarbonitrile

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared in the manner of Example XXXIII, substituting 4-chloro-6-ethylamino-2-isopropylamino-5-pyrimidinecarbonitrile and a solution of sodium in ethanol for 4-chloro-2-(1-cyano-1-methylethylamino)-6-ethylamino-5-pyrimidinecarbonitrile and a solution of sodium in methanol. The reaction product was recrystallized from petroleum ether to give 4-ethoxy-6-ethylamino-2-isopropylamino-5-pyrimidinecarbonitrile; mp, 98°-99°.

Workup

  1. customThis compound was prepared in the manner of Example XXXIII
  2. customThe reaction product was recrystallized from petroleum ether

Sources & evidence

ORD record
ord-de9539452b9d46e28954cdf59ff79508
Source dataset
uspto-grants-1983_02
Patent number
USRE031136

Reaction notes

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