HCID 178478672, compound → HCID 178432400, compound

HRID 1757930Notes

Reaction equation

HRID 1757930 reaction equation
O.Cl.Cl.[NH2:4][C:5]1[C:10]([NH2:11])=[C:9]([OH:12])[N:8]=[C:7]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])[N:6]=1>O>[C:19]([CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][NH:13][C:7]1[N:8]=[C:9]([OH:12])[C:10]2[C:5](=[N:4][C:15]([CH3:14])=[C:16]([CH3:17])[N:11]=2)[N:6]=1)([OH:21])=[O:20]

Participants

3

Reactant 1

HCID 178478672HCID 178478672, compound

Product 1

HCID 178432400HCID 178432400, compoundYield 163.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4.3 g of 4,5-diamino-2-(5-carboxypentylamino)-6-hydroxypyrimidine dihydrochloride monohydrate and 2.5 g of diacetyl were dissolved in 100 ml of water and, after adjusting the pH to 2 to 3, the solution was heated under reflux for 1 hour. After cooling, the precipitate was crystallized from 50% (v/v) methanol, and 3.1 g of 2-(5-carboxypentylamino)-4-hydroxy-6,7-dimethylpteridine was obtained as yellow needles having an m.p. 215°-219° C. (dec.).

Workup

  1. temperaturethe solution was heated
  2. temperatureunder reflux for 1 hour
  3. temperatureAfter cooling
  4. customthe precipitate was crystallized from 50% (v/v) methanol

Sources & evidence

ORD record
ord-3628ad031daf4882a9b429d63f0057b9
Source dataset
uspto-grants-1983_02
Patent number
US04371514

Reaction notes

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