HCID 178478672, compound → HCID 178432400, compound

Participants

Reaction Steps

4.3 g of 4,5-diamino-2-(5-carboxypentylamino)-6-hydroxypyrimidine dihydrochloride monohydrate and 2.5 g of diacetyl were dissolved in 100 ml of water and, after adjusting the pH to 2 to 3, the solution was heated under reflux for 1 hour. After cooling, the precipitate was crystallized from 50% (v/v) methanol, and 3.1 g of 2-(5-carboxypentylamino)-4-hydroxy-6,7-dimethylpteridine was obtained as yellow needles having an m.p. 215°-219° C. (dec.).

Provenance & Evidence