Sodium Hydroxide → ((4-Phenylbutyl)hydroxyphosphoryl)acetic acid

HRID 1757939Notes

Reaction equation

HRID 1757939 reaction equation
C([O:3][P:4]([CH2:16][C:17]([OH:19])=[O:18])([CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:5])C.[OH-].[Na+]>O1CCCC1.CCCCCC>[OH:5][P:4]([CH2:16][C:17]([OH:19])=[O:18])([CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13136848[Ethoxy(4-phenylbutyl)phosphoryl]acetic acid

Product 1

HCID 13102401((4-Phenylbutyl)hydroxyphosphoryl)acetic acid

Reagents, catalysts & solvents 1

HCID 21883165Tetrahydrofuran hexaneSolvent

Procedure

[Ethoxy(4-phenylbutyl)phosphinyl]acetic acid from Example 1(b), is further saponified by heating with excess sodium hydroxide, acidification and recrystallization of the product from tetrahydrofuran/hexane to obtain [hydroxy(4-phenylbutyl)phosphinyl]acetic acid; m.p. 109.5°-110°.

Sources & evidence

ORD record
ord-24d21d33831943fcbfd5a502787f903a
Source dataset
uspto-grants-1983_02
Patent number
US04371526

Reaction notes

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