Potassium Carbonate → HCID 12822119, compound

HRID 1757989Notes

Reaction equation

HRID 1757989 reaction equation
CO[CH:3]([O:10][CH3:11])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:12][O:13][CH:14]1[CH2:19][CH2:18][CH:17]=[CH:16][O:15]1.[C:20](=O)([O-])[O-:21].[K+].[K+]>[Cl-].[Cl-].[Zn+2].O>[CH3:12][O:13][CH:14]1[CH:19]([CH:3]([O:10][CH3:11])[C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:18][CH2:17][CH:16]([O:21][CH3:20])[O:15]1

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 62375Benzaldehyde dimethyl acetalHCID 915383,4-dihydro-2-methoxy-2H-pyran

Product 1

HCID 12822119HCID 12822119, compound

Reagents, catalysts & solvents 2

HCID 3007855ZincchlorideCatalystHCID 962WaterSolvent

Conditions

Temperature
25 °C

Procedure

152 g. (1.0 mole) benzaldehyde dimethyl acetal was combined with 3 g. ZnCl2. While stirring and cooling to 25° C., 114 g. (1 mole) 2-methoxy-2,3-dihydro-4H-pyran was added. After stirring for an hour, the catalyst was neutralized by the addition of 15 g. potassium carbonate in 30 ml. water. The mixture was then extracted with ether and the combined ether extracts were washed with water and dried over sodium sulfate. After the removal of the solvent, the residue was distilled in vacuo to give the title compound; b.p. 120°-128° C. (0.6 mm). Yield: 243 g. (91%).

Workup

  1. stirringAfter stirring for an hour
  2. additionthe catalyst was neutralized by the addition of 15 g
  3. extractionThe mixture was then extracted with ether
  4. washthe combined ether extracts were washed with water
  5. dry with materialdried over sodium sulfate
  6. customAfter the removal of the solvent
  7. distillationthe residue was distilled in vacuo

Sources & evidence

ORD record
ord-fbab302f332e494a915900f58c69133b
Source dataset
uspto-grants-1983_02
Patent number
US04371547

Reaction notes

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