HCID 12850293, compound → HCID 12850294, compound

HRID 1758129Notes

Reaction equation

HRID 1758129 reaction equation
[Br:1][CH2:2][C:3]1[N:7](C(=O)C)[C:6](=[O:11])[N:5]([C:12](=[O:14])[CH3:13])[C:4]=1[C:15]([O:17][CH2:18][CH3:19])=[O:16]>Br.C(O)(=O)C>[C:12]([N:5]1[C:4]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:3]([CH2:2][Br:1])[NH:7][C:6]1=[O:11])(=[O:14])[CH3:13]

Participants

4

Reactant 1

HCID 12850293HCID 12850293, compound

Product 1

HCID 12850294HCID 12850294, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 260Hydrogen BromideSolvent

Procedure

Crude ethyl 5-(bromomethyl)-1,3-diacetyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylate is dissolved in 30% hydrobromic acid in acetic acid and the solution is allowed to stand at room temperature for 4 hours. The solid which precipitates is separated by filtration and dried in vacuo at 80° C. over potassium hydroxide to give ethyl 3-acetyl-5-(bromomethyl)-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylate melting at about 193°-194° C. (dec.).

Workup

  1. customThe solid which precipitates
  2. customis separated by filtration
  3. dry with materialdried in vacuo at 80° C. over potassium hydroxide

Sources & evidence

ORD record
ord-0856bbb19093432cb0204839dffd63f7
Source dataset
uspto-grants-1983_02
Patent number
US04371737

Reaction notes

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