反应详情

A mixture of 21.8 g. (78 mmole) of 3-benzyloxy-4-bromophenol, 20.0 g. (82.6 mmole) of (S)-1-methyl-4-phenylbutyl methane sulfonate and 25.2 g. (200 mmole) of potassijm carbonate in 100 ml. dimethylformamide was heated at 85° C. for 13.5 hours. The reaction was cooled and added to 500 ml. water-500 ml. ether. The organic extract was washed with two 250 ml. portions of water, dried over magnesium sulfate and evaporated to an oil. The crude oil was purified via column chromatography on 750 g. of silica gel eluted with 10% ether-hexane to yield 23.9 g. (72%) of the title compound as an oil.

1. additionA mixture of 21.8 g
2. temperatureThe reaction was cooled
3. additionadded to 500 ml
4. extractionThe organic extract
5. washwas washed with two 250 ml
6. dry with materialportions of water, dried over magnesium sulfate
7. customevaporated to an oil
8. customThe crude oil was purified via column chromatography on 750 g
9. washof silica gel eluted with 10% ether-hexane
10. customto yield 23.9 g