HCID 20509898, compound → HCID 20509920, compound

HRID 1758234Notes

Reaction equation

HRID 1758234 reaction equation
[CH3:1][O:2][CH:3]([O:17][CH3:18])[CH2:4][NH:5][CH2:6][C:7]1[CH:12]=[C:11]([CH3:13])[CH:10]=[CH:9][C:8]=1[N+:14]([O-])=O>C(O)C.[Pd]>[CH3:1][O:2][CH:3]([O:17][CH3:18])[CH2:4][NH:5][CH2:6][C:7]1[CH:12]=[C:11]([CH3:13])[CH:10]=[CH:9][C:8]=1[NH2:14]

Participants

4

Reactant 1

HCID 20509898HCID 20509898, compound

Product 1

HCID 20509920HCID 20509920, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The crude aminoacetal obtained in step (c) is dissolved in 700 ml of ethanol and is hydrogenated at room temperature and at atmospheric pressure, in the presence of 3 g of palladium catalyst (10% Pd on carbon). After the catalyst is filtered off and the filtrate evaporated, the heading compound remains as an orange oil, which is converted into the hydrochloride using methanolic hydrochloric acid.

Workup

  1. filtrationAfter the catalyst is filtered off
  2. customthe filtrate evaporated

Sources & evidence

ORD record
ord-8186f80460ea49798f8a047ceef94a27
Source dataset
uspto-grants-1983_02
Patent number
US04372956

Reaction notes

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