Hydrochloric Acid → HCID 178482013, compound

HRID 1758288Notes

Reaction equation

HRID 1758288 reaction equation
Cl.[CH3:2][N:3]1[C:7]([CH2:8][CH2:9][CH2:10][C:11]([O:13]C)=[S:12])=[N:6][N:5]=[N:4]1>O>[CH3:2][N:3]1[C:7]([CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[S:12])=[N:6][N:5]=[N:4]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54570333HCID 54570333, compound

Product 1

HCID 178482013HCID 178482013, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

20% Hydrochloric acid (150 ml) is added to methyl 4-(1-methyl-1,2,3,4-tetrazol-5-yl)thiobutyrate (17 g) and the mixture is refluxed for 2 hours. After cooling, the reaction mixture is diluted with water and extracted with chloroform. The chloroform solution is washed with saturated aqueous sodium chloride and dried over magnesium sulfate. Chloroform is distilled off to obtain 4-(1-methyl-1,2,3,4-tetrazol-5-yl)thiobutyric acid as colorless liquid, nD26 =1.5133

Workup

  1. temperaturethe mixture is refluxed for 2 hours
  2. temperatureAfter cooling
  3. extractionextracted with chloroform
  4. washThe chloroform solution is washed with saturated aqueous sodium chloride
  5. dry with materialdried over magnesium sulfate
  6. distillationChloroform is distilled off

Sources & evidence

ORD record
ord-1e9655439d2b4d488f8d44d479a9f3f5
Source dataset
uspto-grants-1983_02
Patent number
US04372953

Reaction notes

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