HCID 12806312, compound → HCID 12806313, compound

HRID 1758294Notes

Reaction equation

HRID 1758294 reaction equation
[CH3:1][C:2]1[N:6]([CH2:7][CH2:8][CH2:9][C:10]([O:12]C)=[O:11])[N:5]=[N:4][N:3]=1>Cl>[CH3:1][C:2]1[N:6]([CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])[N:5]=[N:4][N:3]=1

Participants

3

Reactant 1

HCID 12806312HCID 12806312, compound

Product 1

HCID 12806313HCID 12806313, compoundYield 92.5%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

20% Hydrochloric acid (30 ml) is added to methyl 4-(5-methyl-1,2,3,4-tetrazol-1-yl)butyrate (5.5 g) and the mixture is refluxed for 2 hour. The mixture is concentrated to dryness under reduced pressure. Acetone and benzene are added to the residue and water is removed by azeotropic distillation to obtain 4-(5-methyl-1,2,3,4-tetrazol-1-yl)butyric acid (4.7 g) as colorless liquid.

Workup

  1. temperaturethe mixture is refluxed for 2 hour
  2. concentrationThe mixture is concentrated to dryness under reduced pressure
  3. additionAcetone and benzene are added to the residue and water
  4. customis removed by azeotropic distillation

Sources & evidence

ORD record
ord-c97c9a8c0c3c4b40a78bf4a9ee2301a5
Source dataset
uspto-grants-1983_02
Patent number
US04372953

Reaction notes

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