Acetone → HCID 178473693, compound

HRID 1758303Notes

Reaction equation

HRID 1758303 reaction equation
[SH:1][C:2]1[NH:6][N:5]=[N:4][N:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:13][C:14]([CH3:16])=[O:15]>>[C:14]([CH2:16][S:1][C:2]1[NH:6][N:5]=[N:4][N:3]=1)(=[O:15])[CH3:13]

Participants

4

Reactant 3

HCID 180AcetoneHCID 11430Potassium CarbonateHCID 178527994HCID 178527994, compound

Product 1

HCID 178473693HCID 178473693, compound

Procedure

5-Mercapto-1,2,3,4-tetrazole (1 g), potassium carbonate (2 g) and β-chloroacetone (1.4 g) are added to acetone (50 ml) and the solution is refluxed with stirring for 2 hours. The reaction mixture is concentrated to dryness under reduced pressure and the residue is dissolved in chloroform. Insolubles are filtered off and the filtrate is concentrated under reduced pressure. The residue is purified by silica gel column chromatography (Kieselgel 60, eluant: benzene-ether (10:1) to obtain 5-acetylmethylthio-1,2,3,4-tetrazole (0.4 g) as colorless liquid.

Workup

  1. temperaturethe solution is refluxed
  2. concentrationThe reaction mixture is concentrated to dryness under reduced pressure
  3. dissolutionthe residue is dissolved in chloroform
  4. filtrationInsolubles are filtered off
  5. concentrationthe filtrate is concentrated under reduced pressure
  6. customThe residue is purified by silica gel column chromatography (Kieselgel 60, eluant

Sources & evidence

ORD record
ord-c7e52f44d55c4e29bfb4f06df1b9487d
Source dataset
uspto-grants-1983_02
Patent number
US04372953

Reaction notes

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