反应详情

5-Mercapto-1,2,3,4-tetrazole (1 g), potassium carbonate (2 g) and β-chloroacetone (1.4 g) are added to acetone (50 ml) and the solution is refluxed with stirring for 2 hours. The reaction mixture is concentrated to dryness under reduced pressure and the residue is dissolved in chloroform. Insolubles are filtered off and the filtrate is concentrated under reduced pressure. The residue is purified by silica gel column chromatography (Kieselgel 60, eluant: benzene-ether (10:1) to obtain 5-acetylmethylthio-1,2,3,4-tetrazole (0.4 g) as colorless liquid.

1. temperaturethe solution is refluxed
2. concentrationThe reaction mixture is concentrated to dryness under reduced pressure
3. dissolutionthe residue is dissolved in chloroform
4. filtrationInsolubles are filtered off
5. concentrationthe filtrate is concentrated under reduced pressure
6. customThe residue is purified by silica gel column chromatography (Kieselgel 60, eluant