Potassium Carbonate → HCID 13061943, compound

HRID 1758329Notes

Reaction equation

HRID 1758329 reaction equation
[SH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:8][N:9]1[C:13]([S:14][CH2:15][CH2:16][CH2:17][CH2:18]Br)=[N:12][N:11]=[N:10]1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:8][N:9]1[C:13]([S:14][CH2:15][CH2:16][CH2:17][CH2:18][S:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=2)=[N:12][N:11]=[N:10]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 13061933HCID 13061933, compoundHCID 178418616HCID 178418616, compound

Product 1

HCID 13061943HCID 13061943, compoundYield 75.9%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

2-Mercaptopyridine (1.3 g) and 1-methyl-5-(4-bromobutyl)thio-1,2,3,4-tetrazole (2 g) are dissolved in acetone (50 ml). To the mixture is added potassium carbonate (1.4 g), and the mixture is refluxed for 2 hours. After acetone is distilled off, water is added to the residue, and the precipitated crystals are separated by filtration and recrystallized from ethanol-water to give 1-methyl-5-[4-(2-pyridyl)thiobutyl]thio-1,2,3,4-tetrazole (1.7 g) as pale yellow prisms, m.p. 49°-51.5° C.

Workup

  1. temperaturethe mixture is refluxed for 2 hours
  2. distillationAfter acetone is distilled off
  3. additionwater is added to the residue
  4. customthe precipitated crystals are separated by filtration
  5. customrecrystallized from ethanol-water

Sources & evidence

ORD record
ord-e7211c5bc6bd4d26b7d357e6ba3dbf6a
Source dataset
uspto-grants-1983_02
Patent number
US04372953

Reaction notes

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