Methanol → HCID 54021691, compound

HRID 1758400Notes

Reaction equation

HRID 1758400 reaction equation
C([O:3][C:4](=[O:22])[C:5]([C:16]1[N:17]=[C:18]([NH2:21])[S:19][CH:20]=1)=[N:6][O:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=1)C.CN1C=CN=C1.[OH-].[Na+].CO>O1CCCC1>[NH2:21][C:18]1[S:19][CH:20]=[C:16]([C:5](=[N:6][O:7][CH2:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[C:4]([OH:22])=[O:3])[N:17]=1

Participants

6

Reactant 4

HCID 887MethanolHCID 13901-MethylimidazoleHCID 14798Sodium HydroxideHCID 53729747HCID 53729747, compound

Product 1

HCID 54021691HCID 54021691, compoundYield 94.9%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Ethyl-2-(2-aminothiazol-4-yl)-2-(4-fluorobenzyloxyimino)-acetate (syn isomer, 25.5 g.), 1-methylimidazole (1.3 g.), 1 N sodium hydroxide solution (118.3 ml.), methanol (250 ml.) and tetrahydrofuran (200 ml.) were treated in similar manner to that of Example p-(4) to give 2-(2-aminothiazol-4-yl)-2-(4-fluorobenzyloxyimino)acetic acid (syn isomer, 22.11 g.).

Sources & evidence

ORD record
ord-fa1fbf618c2a4779aead7ac3f18a93d1
Source dataset
uspto-grants-1983_02
Patent number
US04372952

Reaction notes

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