HCID 20164527, compound → HCID 86738792, compound

HRID 1758450Notes

Reaction equation

HRID 1758450 reaction equation
[C:1]([CH2:4][CH2:5][C:6]([SH:23])([C:9]1[C:18]2[C:13](=[CH:14][C:15]([O:21][CH3:22])=[C:16]([O:19][CH3:20])[CH:17]=2)[CH2:12][CH2:11][N:10]=1)[C:7]#[N:8])([OH:3])=[O:2]>C(O)C(C)C>[CH3:1][CH:4]([O:2][C:1]([CH2:4][CH2:5][C:6]([SH:23])([C:9]1[C:18]2[C:13](=[CH:14][C:15]([O:21][CH3:22])=[C:16]([O:19][CH3:20])[CH:17]=2)[CH2:12][CH2:11][N:10]=1)[C:7]#[N:8])=[O:3])[CH2:5][CH3:6]

Participants

3

Reactant 1

HCID 20164527HCID 20164527, compound

Product 1

HCID 86738792HCID 86738792, compound

Reagents, catalysts & solvents 1

HCID 6560IsobutanolSolvent

Procedure

Following the procedure described in Example 19 but starting from 1.67 g. of α-(2-carboxyethyl)-mercapto-6,7-dimethoxy-3,4-dihydro-isoquinolyl-acetonitrile and 5 ml. of isobutanol 1.4 g. of α-[2-(2-butoxycarbonyl)-ethyl]-mercapto-6,7-dimethoxy-3,4-dihydro-1-isoquinolyl-acetonitrile are obtained, melting at 120° C. after recrystallization from absolute ethanol.

Sources & evidence

ORD record
ord-ec5abb4cf6ff4bd7b44da037f7516bbd
Source dataset
uspto-grants-1983_02
Patent number
US04373104

Reaction notes

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