HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1758471Generated: October 27, 2026
Methylamine → N-[2-(2-methylamino-2-phenylethyl)phenyl]-2,2-dimethylpropanamide
https://huagongshe.com/reaction/1758471
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | N-[2-(2-chloro-2-phenylethyl)phenyl]-2,2-dimethylpropanamide | HCID 13118178 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | N-[2-(2-methylamino-2-phenylethyl)phenyl]-2,2-dimethylpropanamide | HCID 10968937 | — |
Reaction Steps
N-[2-(2-chloro-2-phenylethyl)phenyl]-2,2-dimethylpropanamide (1.0 g, 3.17 mol) was reacted with monomethyl amine (7 g of 40% aqueous solution) in 2-propanol (3 g). The mixture was heated to 80° C. and stirred for 1 hour. Formation of product was indicated by TLC (silica gel/70 ethyl acetate/30 methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04374067 |
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| Source dataset | uspto-grants-1983_02 |
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| ORD ID | ord-fcf9466688d64eadb5fd3986238c833f |
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| Source note | uspto-grants-1983_02 |
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