Methylamine → N-[2-(2-methylamino-2-phenylethyl)phenyl]-2,2-dimethylpropanamide

HRID 1758471Notes

Reaction equation

HRID 1758471 reaction equation
Cl[CH:2]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11](=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13].[CH3:23][NH2:24]>CC(O)C>[CH3:23][NH:24][CH:2]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11](=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 13118178N-[2-(2-chloro-2-phenylethyl)phenyl]-2,2-dimethylpropanamide

Product 1

HCID 10968937N-[2-(2-methylamino-2-phenylethyl)phenyl]-2,2-dimethylpropanamide

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
80 °C

Procedure

N-[2-(2-chloro-2-phenylethyl)phenyl]-2,2-dimethylpropanamide (1.0 g, 3.17 mol) was reacted with monomethyl amine (7 g of 40% aqueous solution) in 2-propanol (3 g). The mixture was heated to 80° C. and stirred for 1 hour. Formation of product was indicated by TLC (silica gel/70 ethyl acetate/30 methanol).

Sources & evidence

ORD record
ord-fcf9466688d64eadb5fd3986238c833f
Source dataset
uspto-grants-1983_02
Patent number
US04374067

Reaction notes

Loading…