2-Carbamoyl-4,5-difluorobenzoic acid → 5,6-Difluoroisoindoline-1,3-dione

HRID 1758572ノート

反応式

HRID 1758572 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:12]([NH2:14])=[O:13])[C:5](=[CH:9][C:10]=1[F:11])[C:6]([OH:8])=O>C1(C)C=CC=CC=1>[F:11][C:10]1[CH:9]=[C:5]2[C:6](=[O:8])[NH:14][C:12](=[O:13])[C:4]2=[CH:3][C:2]=1[F:1]

参加物

3

反応物 1

HCID 147740022-Carbamoyl-4,5-difluorobenzoic acid

生成物 1

HCID 148182125,6-Difluoroisoindoline-1,3-dione

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

One part of the 4,5-difluorophthalamic acid was heated to 170° C. for a period of 30 minutes, then cooled, dissolved in toluene and crystallized therefrom. The crystalline product was separated by filtration to yield 0.56 parts of 4,5-difluorophthalimide, having a melting range of 154°-156° C. The structure was confirmed by C13 nuclear magnetic resonance analysis.

後処理

  1. temperaturecooled
  2. customcrystallized
  3. customThe crystalline product was separated by filtration

出典と根拠

ORDレコード
ord-e7e024591c554b4896c2dd4263340d27
出典データセット
uspto-grants-1983_02
特許番号
US04374267

反応ノート

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