3-Chlorophthalic anhydride → 3-Fluorophthalic anhydride

HRID 1758573Notes

Reaction equation

HRID 1758573 reaction equation
Cl[C:2]1[CH:12]=[CH:11][CH:10]=[C:4]2[C:5]([O:7][C:8](=[O:9])[C:3]=12)=[O:6].[F-:13].[K+]>>[F:13][C:2]1[CH:12]=[CH:11][CH:10]=[C:4]2[C:5]([O:7][C:8](=[O:9])[C:3]=12)=[O:6]

Participants

3

Reactant 2

HCID 670143-Chlorophthalic anhydrideHCID 522689Potassium Fluoride

Product 1

HCID 695513-Fluorophthalic anhydrideYield 69%

Conditions

Temperature
235 °C

Procedure

A mixture of 20 parts of 3-chlorophthalic anhydride, and 20 parts of anhydrous potassium fluoride was heated and maintained at about 235° C. for about 9 hours. The reaction mixture was then cooled and the crude product removed by vacuum distillation and recrystallized from chloroform to yield 12.65 parts of purified 3-fluorophthalic anhydride (69% yield).

Workup

  1. temperaturewas heated
  2. temperatureThe reaction mixture was then cooled
  3. customthe crude product removed by vacuum distillation
  4. customrecrystallized from chloroform

Sources & evidence

ORD record
ord-3b3a7d01a50646759b9d427d1c4f17f8
Source dataset
uspto-grants-1983_02
Patent number
US04374267

Reaction notes

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