Ammonia → HCID 178456954, compound

HRID 1758630Notes

Reaction equation

HRID 1758630 reaction equation
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][S:11][CH:12]([CH3:15])[CH2:13][NH2:14])[N:9]=1)[C:2]([NH2:4])=[NH:3].COC1C(OC)=NS(=O)N=1.N(C1SC=C(CSC(C)C[NH:39][C:40]2[C:44](OC)=[N:43][S:42](=[O:47])[N:41]=2)N=1)C(N)=N.N>>[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][S:11][CH:12]([CH3:15])[CH2:13][NH:14][C:44]2[C:40]([NH2:39])=[N:41][S:42](=[O:47])[N:43]=2)[N:9]=1)[C:2]([NH2:4])=[NH:3]

Participants

5

Reactant 4

HCID 222AmmoniaHCID 129139473,4-Dimethoxy-1,2,5-thiadiazole 1-oxideHCID 178458092HCID 178458092, compoundHCID 178494325HCID 178494325, compound

Product 1

HCID 178456954HCID 178456954, compound

Procedure

When a methanolic solution of 2-[(guanidinothiazol-4-yl)methylthio]propylamine is reacted with 3,4-dimethoxy-1,2,5-thiadiazole 1-oxide [prepared in Example 4, Step A], and the resultant 3-{2-[(2-guanidinothiazol-4-yl)methylthio]propylamino}-4-methoxy-1,2,5-thiadiazole 1-oxide is treated with excess ammonia by the procedure in Example 35, the title compound is thereby produced.

Sources & evidence

ORD record
ord-54090d1fd5a04c4f9aa84bcd2eff1e07
Source dataset
uspto-grants-1983_02
Patent number
US04374248

Reaction notes

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